Genetic Variation in Drug Transporters in Ethnic Populations

Genetic variation in natural populations

Genetic Variation and Inheritance of Early Growth Characteristics in Three Wild Pistachio Populations

Pistacia atlantica is the most important tree species for the economy of many rural areas in west of Iran, but no effort has been made for the genetic improvement of this species. The aim of this investigation was to study the genetic variation and inheritance of early growth traits in P. atlantica. For this purpose, three wild pistachio populations comprising 60 randomly selected adult trees f...

The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.

BACKGROUND The lung cancer risk of smokers varies by race/ethnicity even after adjustment for smoking. Evaluating the role of genetics in nicotine metabolism is likely important in understanding these differences, as disparities in risk may be related to differences in nicotine dose and metabolism. METHODS We conducted a genome-wide association study in search of common genetic variants that ...

Genetic Variation Within PoPulations

Seven microsatellite loci were used to develop multilocus genotypes for 49 individuals of Neotoma stephensi (Stephen’s woodrat) collected from nine sites in central and northern Arizona. Several statistical analyses were used to determine genetic structure, levels of genetic variability, and degree of relatedness. Structure analyses estimated two distinct groups within localities. The FST value...

Impact of genetic variation in OATP transporters to drug disposition and response.

There has been remarkable progress during the past decade in understanding of how genetic variations in drug metabolizing enzymes and transporters contribute to observed variation in drug responsiveness. Among drug transporters, the organic anion transporting polypeptide (OATP) class of transporters have proven to be remarkably important to the cellular uptake disposition of a variety of clinic...